Hydrophobia is one of the most subtle diseases ever known.  So obscure and uncertain are its phenomena that many able men have been led to doubt the existence of such a disease!  The mythological origin of the malady in the supposed influence of a dog-star seemed to strengthen the view that hydrophobia, as a specific disease, does not exist.  It is undeniably true that the great majority of the cases of so-called rabies are pure myths.  Under investigation they melt away into nothing but alarm and fiction.  However, there appeared to be a residue of actual hydrophobia, though the disease as tested by its name exists in fancy rather than fact.

In any event, Pasteur began to investigate hydrophobia, and at length discovered the bacilli which produce it.  At least he found in animals affected with rabies, notably in the spinal marrow of such animals, minute living organisms, having the form of thread-like animalculae, with heads at one end.  The microscope showed also among these thread-like bodies other organisms that were like small circular black specks, or disks.

The next step in the work was to test the result by inoculating a well animal with these bodies.  Pasteur selected rabbits for his experimentation.  When the experiment was made, the inoculated rabbit was presently attacked with the disease, and soon died in spasms.  The repetition of the experiment was attended with like results.

The philosopher next tried his established method of domesticating, or attenuating, the poison.  The spinal cord of a rabid dog was obtained, and with this the first rabbit was inoculated.  In about two weeks it took hydrophobia.  Hereupon the spinal cord was extracted, and the second rabbit was inoculated; then the third; then the fourth, and so on.  It was observed, however, that at each stage the intensity of the disease was in this way strangely increased; but the period of inoculation became shorter and shorter.

It was next found that by preserving the spinal cords of the animals that had died of the disease—­by preserving them in dry tubes—­the poison gradually lost its power.  At last the virus seemed to die altogether.  Then the experiment of inoculating against the disease was begun.  A dog was first inoculated with dead virus.  No result followed.  Then he was inoculated with stale virus, and then with other virus not so stale.  It was found that by continuing this process the animal might be rendered wholly insusceptible to the disease.

The next step was the human stage of experimentation.  It was in July of 1885 that Pasteur first employed his method on a human subject.  A boy had been bitten and lacerated by a rabid dog.  The inoculation was thought to prove successful.  Soon afterward some bitten children were taken from the United States to Paris, and were treated against the expected appearance of hydrophobia.  Others came from different parts of the continent.  Within fourteen months more than two thousand five hundred subjects were treated, and it is claimed that the mortality from hydrophobia was reduced to a small per cent of what it had been before.