M. Beguelin, in the Berlin Memoires, V. II. 1771, observes, that, when he held a book so that the sun shone upon his half-closed eyelids, the black letters, which he had long inspected, became red, which must have been thus occasioned.  Those parts of the retina which had received for some time the black letters, were so much more sensible than those parts which had been opposed to the white paper, that to the former the red light, which passed through the eyelids, was perceptible.  There is a similar story told, I think, in de Voltaire’s Historical Works, of a Duke of Tuscany, who was playing at dice with the general of a foreign army, and, believing he saw bloody spots upon the dice, portended dreadful events, and retired in confusion.  The observer, after looking for a minute on the black spots of a die, and carelessly closing his eyes, on a bright day; would see the image of a die with red spots upon it, as above explained.

5.  On emerging from a dark cavern, where we have long continued, the light of a bright day becomes intolerable to the eye for a considerable time, owing to the excess of sensibility existing in the eye, after having been long exposed to little or no stimulus.  This occasions us immediately to contract the iris to its smallest aperture, which becomes again gradually dilated, as the retina becomes accustomed to the greater stimulus of the daylight.

The twinkling of a bright star, or of a distant candle in the night, is perhaps owing to the same cause.  While we continue to look upon these luminous objects, their central parts gradually appear paler, owing to the decreasing sensibility of the part of the retina exposed to their light; whilst, at the same time, by the unsteadiness of the eye, the edges of them are perpetually falling on parts of the retina that were just before exposed to the darkness of the night, and therefore tenfold more sensible to light than the part on which the star or candle had been for some time delineated.  This pains the eye in a similar manner as when we come suddenly from a dark room into bright daylight, and gives the appearance of bright scintillations.  Hence the stars twinkle most when the night is darkest, and do not twinkle through telescopes, as observed by Musschenbroeck; and it will afterwards be seen why this twinkling is sometimes of different colours when the object is very bright, as Mr. Melvill observed in looking at Sirius.  For the opinions of others on this subject, see Dr. Priestley’s valuable History of Light and Colours, p. 494.

Many facts observable in the animal system are similar to these; as the hot glow occasioned by the usual warmth of the air, or our clothes, on coming out of a cold bath; the pain of the fingers on approaching the fire after having handled snow; and the inflamed heels from walking in snow.  Hence those who have been exposed to much cold have died on being brought to a fire, or their limbs have become so much inflamed as to mortify.  Hence much food or wine given suddenly to those who have almost perished by hunger has destroyed them; for all the organs of the famished body are now become so much more irritable to the stimulus of food and wine, which they have long been deprived of, that inflammation is excited, which terminates in gangrene or fever.