VI. 1.  The nice actions of the extremities of our various glands are exhibited in their various productions, which are believed to be made by the gland, and not previously to exist as such in the blood.

Thus the glands, which constitute the liver, make bile; those of the stomach make gastric acid; those beneath the jaw, saliva; those of the ears, ear-wax; and the like.  Every kind of gland must possess a peculiar irritability, and probably a sensibility, at the early state of its existence; and must be furnished with a nerve of sense, or of motion, to perceive, and to select, and to combine the particles, which compose the fluid it secretes.  And this nerve of sense which perceives the different articles which compose the blood, must at least be conceived to be as fine and subtile an organ, as the optic or auditory nerve, which perceive light or sound.  See Sect.  XIV. 9.

But in nothing is this nice action of the extremities of the blood-vessels so wonderful, as in the production of contagious matter.  A small drop of variolous contagion diffused in the blood, or perhaps only by being inserted beneath the cuticle, after a time, (as about a quarter of a lunation,) excites the extreme vessels of the skin into certain motions, which produce a similar contagious material, filling with it a thousand pustules.  So that by irritation, or by sensation in consequence of irritation, or by association of motions, a material is formed by the extremities of certain cutaneous vessels, exactly similar to the stimulating material, which caused the irritation, or consequent sensation, or association.

Many glands of the body have their motions, and in consequence their secreted fluids, affected by pleasurable or painful ideas, since they are in many instances influenced by sensitive associations, as well as by the irritations of the particles of the passing blood.  Thus the idea of meat, excited in the minds of hungry dogs, by their sense of vision, or of smell, increases the discharge of saliva, both in quantity and viscidity; as is seen in its hanging down in threads from their mouths, as they stand round a dinner-table.  The sensations of pleasure, or of pain, of peculiar kinds, excite in the same manner a great discharge of tears; which appear also to be more saline at the time of their secretion, from their inflaming the eyes and eye-lids.  The paleness from fear, and the blush of shame, and of joy, are other instances of the effects of painful, or pleasurable sensations, on the extremities of the arterial system.

It is probable, that the pleasurable sensation excited in the stomach by food, as well as its irritation, contributes to excite into action the gastric glands, and to produce a greater secretion of their fluids.  The same probably occurs in the secretion of bile; that is, that the pleasurable sensation excited in the stomach, affects this secretion by sensitive association, as well as by irritative association.