To which end it is requisite, first, That there should be a scrupulous choice, and a strict examination, of the reality, constancy, and certainty of the Particulars that we admit:  This is the first rise whereon truth is to begin, and here the most severe, and most impartial diligence, must be imployed; the storing up of all, without any regard to evidence or use, will only tend to darkness and confusion.  We must not therefore esteem the riches of our Philosophical treasure by the number only, but chiefly by the weight; the most vulgar Instances are not to be neglected, but above all, the most instructive are to be entertain’d; the footsteps of Nature are to be trac’d, not only in her ordinary course, but when she seems to be put to her shifts, to make many doublings and turnings, and to use some kind of art in indeavouring to avoid our discovery.

The next care to be taken, in respect of the Senses, is a supplying of their infirmities with Instruments, and, as it were, the adding of artificial Organs to the natural; this in one of them has been of late years accomplisht with prodigious benefit to all sorts of useful knowledge, by the invention of Optical Glasses.  By the means of Telescopes, there is nothing so far distant but may be represented to our view; and by the help of Microscopes, there is nothing so small, as to escape our inquiry; hence there is a new visible World discovered to the understanding.  By this means the Heavens are open’d, and a vast number of new Stars, and new Motions, and new Productions appear in them, to which all the ancient Astronomers were utterly Strangers.  By this the Earth it self, which lyes so neer us, under our feet, shews quite a new thing to us, and in every little particle of its matter; we now behold almost as great a variety of Creatures, as we were able before to reckon up in the whole Universe it self.

It seems not improbable, but that by these helps the subtilty of the composition of Bodies, the structure of their parts, the various texture of their matter, the instruments and manner of their inward motions, and all the other possible appearances of things, may come to be more fully discovered; all which the ancient Peripateticks were content to comprehend in two general and (unless further explain’d) useless words of Matter and Form.  From whence there may arise many admirable advantages, towards the increase of the Operative, and the Mechanick Knowledge, to which this Age seems so much inclined, because we may perhaps be inabled to discern all the secret workings of Nature, almost in the same manner as we do those that are the productions of Art, and are manag’d by Wheels, and Engines, and Springs, that were devised by humane Wit.