On receiving notice of the disaster which had taken place at the mines, Valdivia hastened to Quillota with a strong body of troops, and took revenge as far as he could on the Quillotans for the death of his soldiers; after which, he constructed a fort in their country in which he left a garrison for the protection of the people employed in the gold mines. Being soon afterwards reinforced by three hundred men from Peru, under the command of Francisco Villagran and Christoval Escobar, he made choice of a beautiful plain near the mouth of the river Coquimbo, at which place there is a very convenient natural harbour, near which he erected in 1544: a city which he named Serena, to serve as a place of arms to protect the northern part of Chili, and to secure the convoys and reinforcements which might come from Peru in that direction. This place is still known in geography by the name of Serena; but in Chili the native name of Coquimbo prevails, as is the case with most of the Spanish cities and towns in Chili.
In the ensuing year, 1545, Valdivia marched into the country of the Promaucians, with the view of extending his conquests to the southwards. Contemporary historians have not left an account of the events of this year, nor of any battles having been fought on this occasion; yet it is hardly to be supposed that this valiant tribe, who had so gloriously repulsed the armies of the Inca and of Almagro, would allow Valdivia to reduce their territory to subjection without a struggle. However this may have been, it is certain that he had the art to persuade the Promaucians to enter into an alliance with him against the other tribes of Chili; as ever since the Spanish armies in Chili have been assisted by Promaucian auxiliaries, owing to which the most rooted antipathy has been constantly entertained by the Araucanians against the remnant of the Promaucians. In the year 1546, Valdivia passed the river Maule, and reduced the natives to obedience from that river to the Itata. While encamped at a place named Quilacura, near the latter river, he was attacked one night by the natives, who destroyed many of his horses, and put him into imminent danger of a total defeat. His loss on this occasion must have been considerable; as he found it necessary to relinquish his plan of farther conquest, and to return to St Jago to wait reinforcements from Peru. As the expected reinforcements did not arrive, and Pastene, who had been sent into Peru to endeavour to procure recruits, brought news in 1547 of the civil war which then raged in Peru, Valdivia determined to go thither in person, expecting to reap some advantages from these revolutionary movements.