maladies and the action of medicaments.  But results which depend on human conscience and intelligence work slowly, and now at the end of 1829, most medical practice was still strutting or shambling along the old paths, and there was still scientific work to be done which might have seemed to be a direct sequence of Bichat’s.  This great seer did not go beyond the consideration of the tissues as ultimate facts in the living organism, marking the limit of anatomical analysis; but it was open to another mind to say, have not these structures some common basis from which they have all started, as your sarsnet, gauze, net, satin, and velvet from the raw cocoon?  Here would be another light, as of oxy-hydrogen, showing the very grain of things, and revising all former explanations.  Of this sequence to Bichat’s work, already vibrating along many currents of the European mind, Lydgate was enamoured; he longed to demonstrate the more intimate relations of living structure, and help to define men’s thought more accurately after the true order.  The work had not yet been done, but only prepared for those who knew how to use the preparation.  What was the primitive tissue?  In that way Lydgate put the question—­ not quite in the way required by the awaiting answer; but such missing of the right word befalls many seekers.  And he counted on quiet intervals to be watchfully seized, for taking up the threads of investigation—­on many hints to be won from diligent application, not only of the scalpel, but of the microscope, which research had begun to use again with new enthusiasm of reliance.  Such was Lydgate’s plan of his future:  to do good small work for Middlemarch, and great work for the world.

He was certainly a happy fellow at this time:  to be seven-and-twenty, without any fixed vices, with a generous resolution that his action should be beneficent, and with ideas in his brain that made life interesting quite apart from the cultus of horseflesh and other mystic rites of costly observance, which the eight hundred pounds left him after buying his practice would certainly not have gone far in paying for.  He was at a starting-point which makes many a man’s career a fine subject for betting, if there were any gentlemen given to that amusement who could appreciate the complicated probabilities of an arduous purpose, with all the possible thwartings and furtherings of circumstance, all the niceties of inward balance, by which a man swims and makes his point or else is carried headlong.  The risk would remain even with close knowledge of Lydgate’s character; for character too is a process and an unfolding.  The man was still in the making, as much as the Middlemarch doctor and immortal discoverer, and there were both virtues and faults capable of shrinking or expanding.  The faults will not, I hope, be a reason for the withdrawal of your interest in him.  Among our valued friends is there not some one or other who is a little too self-confident and disdainful; whose distinguished