Ferdinand afterwards died without issue, and Vincenzo likewise died childless; and Charles Gonzaga of Nevers-Rethel, who had married Maria, Ferdinand’s ward, became heir to the Duchy of Mantua, but his right was disputed by Ferrante Gonzaga of Guastalla. Charles hurriedly and half secretly introduced himself into Mantua without consultation with Venetian, Spaniard, or German. While Duke Olivares of Spain was meditating his recognition, his officer at Milan tried to seize Mantua and failed; but the German Emperor had been even more deeply offended, and claimed the remission of Charles’s rights as a feudatory of the Roman Empire, until he should have regularly invested him. Charles prepared for defense. Meanwhile Spain and Savoy seized Monferrato, but they were afterwards defeated by the French, and the Spanish Milanese was overrun by the Venetians and Mantuans. The German Emperor then sent down his Landsknechts, and in 1630 besieged Mantua, while the French promised help and gave none, and the Pope exhorted Charles to submit. The Venetians, occupied with the Uskok pirates, could do little in his defense. To the horrors of this unequal and desperate war were added those of famine; and the Jews, passing between the camp and the city, brought a pest from the army into Mantua, which raged with extraordinary violence among the hungry and miserable people. In vain they formed processions, and carried the blood of Christ about the city. So many died that there were not boats enough to bear them away to their sepulture in the lakes, and the bodies rotted in the streets. There was not wanting at this time the presence of a traitor in the devoted city; and that this wretch was a Swiss will be a matter of no surprise. The despicable valor of these republicans has everywhere formed the best defense of tyrants, and their fidelity has always been at the service of the highest bidder. The recreant was a lieutenant in the Swiss Guard of the Duke; and when he had led the Germans into Mantua, and received the reward of his infamy, two German soldiers, placed over him for his protection, killed him and plundered him of his spoil.