for the past twenty-six years, has been subject to the most regularly occurring brain-exaltation every four weeks, almost to a day.  It sometimes passes off without becoming acutely maniacal, or even showing itself in outward acts; at other times it becomes so, and lasts for periods of from one to four weeks.  It is always preceded by an uncomfortable feeling in the head, and pain in the back, mental hebetude, and slight depression.  The nisus generativus is greatly increased, and he says that, if in that condition, he has full and free seminal emissions during sleep, the excitement passes off; if not, it goes on.  A full dose of bromide or iodide of potassium often, but not always, has the effect of stopping the excitement, and a very long walk sometimes does the same.  When the excitement gets to a height, it is always followed by about a week of stupid depression.”  In the same article Clouston remarks:  “I have for a long time been impressed with the relationship of the mental and bodily alternations and periodicities in insanity to the great physiological alternations and periodicities, and I have generally been led to the conclusion that they are the same in all essential respects, and only differ in degree of intensity or duration.  By far the majority of the cases in women follow the law of the menstrual and sexual periodicity; the majority of the cases in men follow the law of the more irregular periodicities of the nisus generativus in that sex.  Many of the cases in both sexes follow the seasonal periodicity which perhaps in man is merely a reversion to the seasonal generative activities of the majority of the lower animals.”  He found that among 338 cases of insanity, chiefly mania and melancholia, 46 per cent, of females and 40 per cent, of males showed periodicity,—­diurnal, monthly, seasonal, or annual, and more marked in women than in men, and in mania than in melancholia,—­and adds:  “I found that the younger the patient, the greater is the tendency to periodic remission and relapse.  The phenomenon finds its acme in the cases of pubescent and adolescent insanity.”

    Conolly Norman, in the article “Mania, Hysterical” (Tuke’s
    Psychological Dictionary), states that “the activity of the
    sexual organs is probably in both sexes fundamentally periodic.”

Krafft-Ebing records the case of a neurasthenic Russian, aged 24, who experienced sexual desires of urologinic character, with fair regularity, every four weeks (Psychopathia Sexualis), and Naecke mentions the case of a man who had nocturnal emissions at intervals of four weeks (Archiv fuer Kriminal-Anthropologie, 1908, p. 363), while Moll (Libido Sexualis, Bd.  I, pp. 621-623) recorded the case of a man, otherwise normal, who had attacks of homosexual feeling every four weeks, and Rohleder (Zeitschrift fuer Sexualwissenschaft, Nov., 1908) gives the case of an unmarried slightly neuropathic physician