In the year 1580, a dangerous war broke out in India against the Portuguese, by a confederacy which had been negotiating for five years with wonderful secrecy. The confederated princes were Adel Khan, Nizam al Mulk, the Zamorin, and the king of Acheen, and they flattered themselves in the hope of extirpating the Portuguese from India, making themselves so sure of success, that they agreed beforehand on the division of their expected conquests. Adel Khan was to have Goa, Onor, and Barcalor; Nizam al Mulk to have Chaul, Daman, and Basseen; and Cananor, Mangalor, Cochin, and Chale were to become the share of the Zamorin. At the same time, the king of Acheen was to attack Malacca, that the Portuguese, assailed at once on every important point, might be incapable of sending succours to the different places. Adel Khan was so confident of success, that he had assigned the different offices at Goa among his chiefs, and had even allotted among them certain Portuguese ladies, who were celebrated for their beauty.
In pursuance of this league, Adel Khan took the field to besiege Goa, and Nizam al Mulk marched against Chaul. In this great emergency, it was recommended by many to abandon Chaul for the greater security of Goa; but the viceroy undauntedly resolved to defend both. Don Francisco Mascarenhas was sent with six hundred men in four gallies and five small vessels for the relief of Chaul, about the beginning of September, and the viceroy took proper precautions for the defence of Goa. The pass of Benastarim was committed to the care of Ferdinand de Sousa y Castellobranco with 120 men. Paul de Lima had charge of Rachol with sixty, and fifteen hundred native troops were distributed in different parts of the island under approved commanders. At this time there were only 700 Portuguese troops in Goa, which were kept as a body of reserve, whenever their services might be most wanted. The defence of the city was confided to the monks and clergy, to the number of 300, assisted by 1000 slaves. Juan de Sousa with 50 horse was ready to give assistance where wanted. Don George de Menezes had the defence of the river with 25 vessels; and the viceroy, having procured ammunition and provisions from all quarters, took post about the middle of December on the bank of the river.