In the year 1527, it being understood at Cochin that Pedro de Mascarenas was on his way from Malacca to assume the government, Lope Vaz de Sampayo who acted ad interim, held a council of the principal officers, at which it was resolved not to admit Mascarenas to that high office. After this determination, Sampayo sailed for Goa, leaving Alphonso Mexia to command at Cochin, with orders to execute the resolutions of the council. On landing unarmed at Cochin, Mascarenas was opposed and wounded by Mexia; and proceeding afterwards to Goa, be was made prisoner and put in irons by order of Sampayo. These violent proceedings had nearly occasioned a civil war among the Portuguese in India; but at length, in the end of December 1527, Sampayo was confirmed in the government, and Mascarenas went home to Portugal, where he was appointed to the command of Azamor in Africa.
In the year 1528, Don Joan Deza was sent to cruise on the coast of Calicut, where in several rencounters he took fifty vessels laden with various commodities. He burnt the town of Mangalore; and falling in with the fleet of Calicut, consisting of seventy paraos well manned and armed under the command of the Chinese admiral Cutiale, Deza took most of them killing 1500 Moors, and taking nearly as many prisoners, among whom was Cutiale.
Antonio Miranda de Azevedo was sent in the end of January 1528 to the Red Sea, with twenty ships and above 1000 soldiers, to endeavour to burn the Turkish gallies in the port of Kamaran which had formerly belonged to Reis Soliman. After taking some prizes by the way, be met with Enrique de Macedo in the mouth of the Red Sea, who had engaged a large Turkish galleon. The Turks had boarded him, and threw a burning dart which stuck in his main-sail and began to set it on fire; but in consequence of a strong gust of wind shaking the sail, the dart fell back into the Turkish vessel, where it set fire to the powder and the ship and all her crew were blown up. Several other valuable ships belonging to the Moors were taken, but the main object of this expedition completely failed, as the wind did not allow the fleet to get up the Red Sea to Kamaran.