therefore coca managed as the great mass of it is must be nearly all of it comparatively worthless.  If used as tea is, this would probably soon appear; but when used as a medicine which has been highly extolled and well advertised, it seems to go on equally well whether of good or bad quality.  It is pretty safe to say that nineteen-twentieths of the coca seen in this market within the past two years must be almost inert and valueless, yet all is sold and used, and its reputation as a therapeutic agent is pretty well kept up.  At least many thousands of pounds of the brown ill-smelling leaf, and of preparations made from it, are annually sold.  And worse than this, considerable quantities of a handsome looking green leaf, well put up and well taken care of, have been sold and used as coca, when wanting in nearly all its characteristics.

The writer for more than a year past has seen but one or two small lots of moderately good coca, and in common with other buyers has been obliged to buy the best that could be found to keep up his supply of the fluid extract.  Almost every purchase has been made on mental protest, and he has been ashamed of every pound of fluid extract sent out, from the knowledge that it was of poor quality; and there seems to be no more prospect of a supply of better quality than there was this time last year, because so long as an inferior quality sells in such enormous quantities at good prices the demands of trade are satisfied.

Under this condition of the markets, the writer has finally decided to give up making a fluid extract of coca, and has left it off his list, adopting a fluid extract of tea instead, as a superior substitute, for those who may choose to use it, and regrets that this course was not taken a year ago.

The character of coca as a therapeutic agent is not very good.  The florid stories of a multitude of travelers and writers, up to and including the testimony of Dr. Mantegazza, received a considerable support from so good an authority as Sir Robert Christison, who reported very definite results from trials made upon himself, and upon several students under his immediate control and observation; and his results seem to have led to a very careful and exhaustive series of observations at University College, London, by Mr. Dowdeswell.  This paper, published in The Lancet of April 29 and May 6, 1876, pp. 631 and 664, is entitled “The Coca Leaf:  Observations on the Properties and Action of the Leaf of the Coca Plant (Erythroxylon coca), made in the Physiological Laboratory of University College, by G.F.  Dowdeswell, B.A.”  The results of these investigations were absolutely negative, and at the close of the work the investigator says:  “Without asserting that it is positively inert, it is concluded from these experiments that its action is so slight as to preclude the idea of its having any value either therapeutically or popularly; and it is the belief of the writer, from observation upon the effect on the pulse, etc., of tea, milk and water, and even plain water, hot, tepid, and cold, that such things may, at slightly different temperatures, produce a more decided effect than even large doses of coca, if taken at about the temperature of the body.”