It is just after the Council of Ephesus that history first makes mention of a supposed authentic portrait of the Virgin Mary. The Empress Eudocia, when travelling in the Holy Land, sent home such a picture of the Virgin holding the Child to her sister-in-law Pulcheria, who placed it in a church at Constantinople. It was at that time regarded, as of very high antiquity, and supposed to have been painted from the life. It is certain that a picture, traditionally said to be the same which Eudocia had sent to Pulcheria, did exist at Constantinople, and was so much venerated by the people as to be regarded as a sort of palladium, and borne in a superb litter or car in the midst of the imperial host, when the emperor led the army in person. The fate of this relic is not certainly known. It is said to have been taken by the Turks in 1453, and dragged through the mire; but others deny this as utterly derogatory to the majesty of the Queen of Heaven, who never would have suffered such an indignity to have been put on her sacred image. According to the Venetian legend, it was this identical effigy which was taken by the blind old Dandolo, when he besieged and took Constantinople in 1204, and brought in triumph to Venice, where it has ever since been preserved in the church of St. Mark, and held in somma venerazione. No mention is made of St. Luke in the earliest account of this picture, though like all the antique effigies of uncertain origin, it was in after times attributed to him.
The history of the next three hundred years testifies to the triumph of orthodoxy, the extension and popularity of the worship of the Virgin, and the consequent multiplication of her image in every form and material, through the whole of Christendom.