We must not, however, rest here if we wish to attain promptly the end proposed, namely, that of planting colonies in malarious districts without exposing the colonists to grave danger.  Even if we realize perfectly the hope which I conceived in 1880, and if we are enabled to prove that arsenic increases man’s power of resistance to the assaults of malaria, we must not imagine that everything is accomplished.  It will take a long time before the use of a preservative method of this kind becomes generalized; we have first to contend against the fear which nearly every one experiences when arsenic is mentioned, and then there will also be difficulty in establishing everywhere a proper control over its administration.  In every attempt at the colonization of malarious regions it will be necessary to combat for a long time the diseases caused by malaria, and we must seek for a method of combating them by a means which is in the possession of everybody, and which shall not be dangerous to the general economy of the human organism.  Those who do not know from actual experience the miseries of a malarious country, think only of combating the acute forms of infection, which often place the patient in danger of death.  But this danger, though great, is for the most part imaginary, provided that assistance be obtained in time.  But that which desolates families, and which causes a physical degradation of the human race exposed to the attacks of malaria, is the chronic poisoning, which undermines the springs of life and produces a slow but progressive anaemia.  This infection often resists all human therapeutic measures, and is even aggravated by the use of quinine, which is given during the recurrent paroxysms of fever.  Quinine is, when given for a long period of time, a true poison to the vaso-motor nerves.  The question, then, is to replace quinine, and the alkaloids which possess an analogous physiological action, by an agent the efficacy of which against, chronic malarial poisoning may be greater and the dangers of its employment less.

THE LEMON FOR MALARIA.

A happy chance has led Dr. Magliori to the discovery of an agent of this sort which was traditionally in use by certain Italian families.  It is an exceedingly simple thing—­merely a decoction of lemon.  It is prepared by cutting up one lemon, peel and all, into thin slices, which are then put into three glassfuls of water and the whole boiled down to one glassful.  It is then strained through linen, squeezing the remains of the boiled lemon, and set aside for some hours to cool.  The whole amount of the liquid is then taken fasting.  It is well known that in Italy, Greece, and North Africa, they often use lemon juice or a decoction of lemon seeds, as a remedy in malarial fevers of moderate intensity; and in Guadaloupe they use for the same purpose a decoction of the bark of the roots of the lemon tree.  All these popular practices tend to show that the lemon tree produces