Not long after the death of Burrus, when Nero began to add sacrilege to his other crimes, Seneca made one more attempt to retire from Rome; and, when permission was a second time refused, he feigned a severe illness, and confined himself to his chamber.  It was asserted, and believed, that about this time Nero made an attempt to poison him by the instrumentality of his freedman Cleonicus, which was only defeated by the confession of an accomplice or by the abstemious habits of the philosopher who now took nothing but bread and fruit, and never quenched his thirst except out of the running stream.

It was during those two years of Seneca’s seclusion and disgrace that an event happened of imperishable interest.  On the orgies of a shameful court, on the supineness of a degenerate people, there burst—­as upon the court of Charles II.—­a sudden lightning-flash of retribution.  In its character, in its extent, in the devastation and anguish of which it was the cause, in the improvements by which it was followed, in the lying origin to which it was attributed, even in the general circumstances of the period and character of the reign in which it happened, there is a close and singular analogy between the Great Fire of London in 1666 and the Great Fire of Rome in 64.  Beginning in the crowded part of the city, under the Palatine and Caelian Hills, it raged, first for six, and then again for three days, among the inflammable material of booths and shops, and driven along by a furious wind, amid feeble and ill-directed efforts to check its course, it burst irresistibly over palaces, temples, and porticoes, and amid the narrow tortuous streets of old Rome, involving in a common destruction the most magnificent works of ancient art, the choicest manuscripts of ancient literature, and the most venerable monuments of ancient superstition.  In a few touches of inimitable compression, such as the stern genius of the Latin language permits, but which are too condensed for direct translation, Tacitus has depicted the horror of the scene,—­wailing of panic-stricken women, the helplessness of the very aged and the very young, the passionate eagerness for themselves and for others, the dragging along of the feeble or the waiting for them, the lingering and the hurry, the common and inextricable confusion.  Many, while they looked backward, were cut off by the flames in front or at the sides; if they sought some neighboring refuge, they found it in the grasp of the conflagration; if they hurried to some more distant spot, that too was found to be involved in the same calamity.  At last, uncertain what to seek or what to avoid, they crowded the streets, they lay huddled together in the fields.  Some, having lost all their possessions, died from the want of daily food; and others, who might have escaped died of a broken heart from the anguish of being bereaved of those whom they had been unable to rescue; while, to add to the universal horror, it was believed that all attempts to repress the flames were checked by authoritive prohibition; nay more, that hired incendiaries were seen flinging firebrands in new directions, either because they had been bidden to do so, or that they might exercise their rapine undisturbed.