patient, that from melancholy became epileptic and blind. [2730]If it come from a cold cause, or so continue cold, or increase, epilepsy; convulsions follow, and blindness, or else in the end they are moped, sottish, and in all their actions, speeches, and gestures, ridiculous. [2731]If it come from a hot cause, they are more furious, and boisterous, and in conclusion mad. Calescentem melancholiam saepius sequitur mania. [2732]If it heat and increase, that is the common event, [2733]_per circuitus, aut semper insanit_, he is mad by fits, or altogether.  For as [2734]Sennertus contends out of Crato, there is seminarius ignis in this humour, the very seeds of fire.  If it come from melancholy natural adust, and in excess, they are often demoniacal, Montanus.

[2735]Seldom this malady procures death, except (which is the greatest, most grievous calamity, and the misery of all miseries,) they make away themselves, which is a frequent thing, and familiar amongst them.  ’Tis [2736]Hippocrates’ observation, Galen’s sentence, Etsi mortem timent, tamen plerumque sibi ipsis mortem consciscunt, l. 3. de locis affec. cap. 7. The doom of all physicians.  ‘Tis [2737]Rabbi Moses’ Aphorism, the prognosticon of Avicenna, Rhasis, Aetius, Gordonius, Valescus, Altomarus, Salust.  Salvianus, Capivaccius, Mercatus, Hercules de Saxonia, Piso, Bruel, Fuchsius, all, &c.

[2738] “Et saepe usque adeo mortis formidine vitae
        Percipit infelix odium lucisque videndae,
        Ut sibi consciscat maerenti pectore lethum.”

       “And so far forth death’s terror doth affright,
        He makes away himself, and hates the light
        To make an end of fear and grief of heart,
        He voluntary dies to ease his smart.”

In such sort doth the torture and extremity of his misery torment him, that he can take no pleasure in his life, but is in a manner enforced to offer violence unto himself, to be freed from his present insufferable pains.  So some (saith [2739]Fracastorius) “in fury, but most in despair, sorrow, fear, and out of the anguish and vexation of their souls, offer violence to themselves:  for their life is unhappy and miserable.  They can take no rest in the night, nor sleep, or if they do slumber, fearful dreams astonish them.”  In the daytime they are affrighted still by some terrible object, and torn in pieces with suspicion, fear, sorrow, discontents, cares, shame, anguish, &c. as so many wild horses, that they cannot be quiet an hour, a minute of time, but even against their wills they are intent, and still thinking of it, they cannot forget it, it grinds their souls day and night, they are perpetually tormented, a burden to themselves, as Job was, they can neither eat, drink or sleep.  Psal. cvii. 18.  “Their soul abhorreth all meat, and they are brought to death’s door, [2740]being bound in misery and iron:”  they [2741]curse their stars with Job, [2742]"and day