But the most immediate symptoms proceed from the temperature itself, and the organical parts, as head, liver, spleen, mesaraic veins, heart, womb, stomach, &c., and most especially from distemperature of spirits (which, as [2543]Hercules de Saxonia contends, are wholly immaterial), or from the four humours in those seats, whether they be hot or cold, natural, unnatural, innate or adventitious, intended or remitted, simple or mixed, their diverse mixtures, and several adustions, combinations, which may be as diversely varied, as those [2544]four first qualities in [2545] Clavius, and produce as many several symptoms and monstrous fictions as wine doth effect, which as Andreas Bachius observes, lib. 3. de vino, cap. 20. are infinite.  Of greater note be these.

If it be natural melancholy, as Lod.  Mercatus, lib. 1. cap. 17. de melan. T. Bright. c. 16. hath largely described, either of the spleen, or of the veins, faulty by excess of quantity, or thickness of substance, it is a cold and dry humour, as Montanus affirms, consil. 26 the parties are sad, timorous and fearful.  Prosper Calenus, in his book de atra bile, will have them to be more stupid than ordinary, cold, heavy, solitary, sluggish. Si multam atram bilem et frigidam habent.  Hercules de Saxonia, c. 19. l. 7. [2546]"holds these that are naturally melancholy, to be of a leaden colour or black,” and so doth Guianerius, c. 3. tract. 15. and such as think themselves dead many times, or that they see, talk with black men, dead men, spirits and goblins frequently, if it be in excess.  These symptoms vary according to the mixture of those four humours adust, which is unnatural melancholy.  For as Trallianus hath written, cap. 16. l. 7. [2547]"There is not one cause of this melancholy, nor one humour which begets, but divers diversely intermixed, from whence proceeds this variety of symptoms:”  and those varying again as they are hot or cold. [2548]"Cold melancholy” (saith Benedic.  Vittorius Faventinus pract. mag.) “is a cause of dotage, and more mild symptoms, if hot or more adust, of more violent passions, and furies.”  Fracastorius, l. 2. de intellect. will have us to consider well of it, [2549]"with what kind of melancholy every one is troubled, for it much avails to know it; one is enraged by fervent heat, another is possessed by sad and cold; one is fearful, shamefaced; the other impudent and bold;” as Ajax, Arma rapit superosque furens inpraelia poscit:  quite mad or tending to madness. Nunc hos, nunc impetit illos. Bellerophon on the other side, solis errat male sanus in agris, wanders alone in the woods; one despairs, weeps, and is weary of his life, another laughs, &c.  All which variety is produced from the several degrees of heat and cold, which [2550]Hercules de Saxonia will have wholly proceed from the distemperature of spirits alone, animal especially, and those immaterial, the next and immediate causes