There is almost no part of the body, which being distempered, doth not cause this malady, as the brain and his parts, heart, liver, spleen, stomach, matrix or womb, pylorus, mirach, mesentery, hypochondries, mesaraic veins; and in a word, saith [2412]Arculanus, “there is no part which causeth not melancholy, either because it is adust, or doth not expel the superfluity of the nutriment.”  Savanarola Pract. major. rubric. 11.  Tract. 6. cap. 1. is of the same opinion, that melancholy is engendered in each particular part, and [2413]Crato in consil. 17. lib. 2. Gordonius, who is instar omnium, lib. med. partic. 2. cap. 19. confirms as much, putting the [2414]"matter of melancholy, sometimes in the stomach, liver, heart, brain, spleen, mirach, hypochondries, when as the melancholy humour resides there, or the liver is not well cleansed from melancholy blood.”

The brain is a familiar and frequent cause, too hot, or too cold, [2415] “through adust blood so caused,” as Mercurialis will have it, “within or without the head,” the brain itself being distempered.  Those are most apt to this disease, [2416]"that have a hot heart and moist brain,” which Montaltus cap. 11. de Melanch. approves out of Halyabbas, Rhasis, and Avicenna.  Mercurialis consil. 11. assigns the coldness of the brain a cause, and Salustius Salvianus med. lect. l. 2. c. 1. [2417]will have it “arise from a cold and dry distemperature of the brain.”  Piso, Benedictus Victorius Faventinus, will have it proceed from a [2418]"hot distemperature of the brain;” and [2419]Montaltus cap. 10. from the brain’s heat, scorching the blood.  The brain is still distempered by himself, or by consent:  by himself or his proper affection, as Faventinus calls it, [2420]"or by vapours which arise from the other parts, and fume up into the head, altering the animal facilities.”

Hildesheim spicel. 2. de Mania, thinks it may be caused from a [2421] “distemperature of the heart; sometimes hot; sometimes cold.”  A hot liver, and a cold stomach, are put for usual causes of melancholy:  Mercurialis consil. 11. et consil. 6. consil. 86. assigns a hot liver and cold stomach for ordinary causes. [2422]Monavius, in an epistle of his to Crato in Scoltzius, is of opinion, that hypochondriacal melancholy may proceed from a cold liver; the question is there discussed.  Most agree that a hot liver is in fault; [2423]"the liver is the shop of humours, and especially causeth melancholy by his hot and dry distemperature.” [2424]"The stomach and mesaraic veins do often concur, by reason of their obstructions, and thence their heat cannot be avoided, and many times the matter is so adust and inflamed in those parts, that it degenerates into hypochondriacal melancholy.”  Guianerius c. 2.  Tract. 15. holds the mesaraic veins to be a sufficient [2425]cause alone.  The spleen concurs to this malady, by all their consents, and suppression of haemorrhoids, dum non expurget alter