But the century was not out of its second decade when signs of an awakening from this lethargy began to show themselves. The first steps, naturally, were along preparatory lines, and for those we are largely indebted to the physicists, the chemists, and the botanists. Gross anatomy became better known, owing for the most part to more enlightened legislation on the subject of the dissection of the human body; minute anatomy (histology) sprang into existence as the result of improvements of the compound microscope. Physiology took on something of the experimental; and medication was rendered far less gross and repulsive by the isolation of the active principles of medicinal plants. But it was long after all this that the telling strides were taken. Up to within the memory of many men who are now living, “peritonitis” tortured its victims to death, said “peritonitis” being often interpreted as a manifestation of rheumatism, for example, and no well-directed interposition was attempted against it, whereas we now know perfectly well that the vast majority of cases of peritonitis are due to local septic poisoning and for the most part quite readily remediable by the removal (with a minimum of danger) of the organ from which such poisoning arises—almost always the vermiform appendix. “Appendicitis,” of which we hear so much nowadays, is no new disease; it is simply the “peritonitis” that killed so many people in former times. But while no well-informed person would now maintain that this disease was a new one, there are many, and those, too, among the best instructed, who find it difficult to avoid the conclusion that, if not new, it must at least be of far more frequent occurrence than formerly. It must be borne in mind, however, that in the great majority of instances in past years it ended spontaneously in recovery and was forgotten.