Lady Mary passed away on August 21, 1762, at the age of seventy-three.  Her remains were interred in the graveyard of Grosvenor Chapel, where also lie Ambrose Phillips, David Mallett, Lord Chesterfield, William Whitehead, John Wilkes, and Elizabeth Carter.

All that Lady Mary possessed, except some trifling legacies, she left to Lady Bute.  Her fortune is believed to have been inconsiderable, except for some valuable jewels.  Walpole had one last gibe:  “With her usual maternal tenderness and usual generosity, she has left her son one guinea.”  The gibe was unworthy, because Walpole knew quite well the career of that son, who, anyhow, was sufficiently provided for.  It may be that it was the pricking of Walpole’s conscience for this last outburst that made him later administer a stern rebuke to Lady Craven.  “I am sorry to hear, Madam, that by your account Lady Mary Wortley was not so accurate and faithful as modern travellers.  The invaluable art of inoculation, which she brought from Constantinople, so dear to all admirers of beauty, and to which we owe, perhaps the preservation of yours, stamps her an universal benefactress; and as you rival her in poetic talents I had rather you would employ them to celebrate her for her nostrum, than detect her for romancing.”