Sharks have shown themselves to be possessed of ossified vertebrae, while the majority of modern Sharks possess such vertebrae.  Again, the more ancient Crocodilia and Lacertilia have vertebrae with the articular facets of their centra flattened or biconcave, while the modern members of the same group have them procoelous.  But the most remarkable examples of progressive modification of the vertebral column, in correspondence with geological age, are those afforded by the Pycnodonts among fish, and the Labyrinthodonts among Amphibia.

The late able ichthyologist Heckel pointed out the fact, that, while the Pycnodonts never possess true vertebral centra, they differ in the degree of expansion and extension of the ends of the bony arches of the vertebrae upon the sheath of the notochord; the Carboniferous forms exhibiting hardly any such expansion, while the Mesozoic genera present a greater and greater development, until, in the Tertiary forms, the expanded ends become suturally united so as to form a sort of false vertebra.  Hermann von Meyer, again, to whose luminous researches we are indebted for our present large knowledge of the organisation of the older Labyrinthodonts, has proved that the Carboniferous Archegosaurus had very imperfectly developed vertebral centra, while the Triassic Mastodonsaurus had the same parts completely ossified.[6]

[Footnote 6:  As this Address is passing through the press (March 7, 1862), evidence lies before me of the existence of a new Labyrinthodont (Pholidogaster), from the Edinburgh coal-field with well-ossified vertebral centra.]

The regularity and evenness of the dentition of the Anoplotherium, as contrasted with that of existing Artiodactyles, and the assumed nearer approach of the dentition of certain ancient Carnivores to the typical arrangement, have also been cited as exemplifications of a law of progressive development, but I know of no other cases based on positive evidence which are worthy of particular notice.

What then does an impartial survey of the positively ascertained truths of palaeontology testify in relation to the common doctrines of progressive modification, which suppose that modification to have taken place by a necessary progress from more to less embryonic forms, or from more to less generalised types, within the limits of the period represented by the fossiliferous rocks?

It negatives those doctrines; for it either shows us no evidence of any such modification, or demonstrates it to have been very slight; and as to the nature of that modification, it yields no evidence whatsoever that the earlier members of any long-continued group were more generalised in structure than the later ones.  To a certain extent, indeed, it may be said that imperfect ossification of the vertebral column is an embryonic character; but, on the other hand, it would be extremely incorrect to suppose that the vertebral columns of the older Vertebrata are in any sense embryonic in their whole structure.