Helene Doris Gayle (born 1955) is an AIDS researcher and epidemiologist for the Centers for Disease Control in Atlanta, Georgia.

Helene Doris Gayle is a specialist in the epidemiology of acquired immune deficiency syndrome (AIDS) and the human immunodeficiency virus (HIV) in children and teenagers. She is the coordinator of the AIDS Agency and chief of the HIV/AIDS Division at the U.S. Agency for International Development, Office of Health. In her position she has traveled to Africa and Asia to investigate the ways the disease affects different societies and to help coordinate international efforts to study it.

Born the third of five children on August 16, 1955, in Buffalo, New York. Her father, Jacob Sr., was an entrepreneur and her mother, Marietta, was a psychiatric social worker. Gayle was influenced by her parents from an early age, for her parents impressed upon their children the importance of making a...