Design for Dying was published in the United States in 1997, a year after Timothy Leary died. Although most of the book is written from Leary's point of view, R. U. Sirius played a major part in editing it, shaping various essays and notes of Leary's into a coherent text. Sirius's voice is as prominent as Leary's. The book resembles a casebook in form, with three major sections labeled "Living," "Dying," and "Designer Dying," and an addendum. Each section is further broken down into short chapters with headings such as "Drugs,' ' "Death is the Ultimate Trip," "The Cryonics Option," and so forth. Leary expounds on his theories, reflects on his experiences, and offers advice on independent living and dying. The addendum contains Leary's friends' and acquaintances' reflections on Leary, including their favorite memories of him. These eulogizers constitute a veritable index of the American counterculture of the last thirty years

The book is most productively read as Leary's theoretical autobiography. Although Leary includes anecdotes and a discussion of the events in his life, the bulk of the writing comprises Leary's iconoclastic reading of the meaning and art of existence. The themes he addresses are the ones that have occupied him for most of his life: drugs, sex, individual freedom, psychology, death, and technology. A complement to his website, which tracked Leary's movements and condition during his last days, Design for Dying offers the thoughts of one of the twentieth-century's most controversial thinkers and cultural figures.